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Provisional Agenda |
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Day 1 - 7 May 2008
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| 07:30 |
Registration |
| 08:30 |
Microarray Diagnostics
Chaired by Steven Bodovitz, Principal, BioPerspectives / Select Biosciences |
| 08:35 |
Market Opportunities and Challenges for Multiplexed Diagnostics
Steven Bodovitz, Principal, BioPerspectives / Select Biosciences
Multiplexed diagnostics are at an early stage of development. Some are relatively straightforward combinations of separate analyses, but others are truly multivariate and have the opportunity for first-mover advantage but also the challenge of acceptance by physicians and payers. |
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09:05 |
Trends in the Market Opportunities for Microarray Technologies
Kenneth G. Krul, President, BioTechTelligence
Microarray technology has been with us for over two decades now. In that time, there have been great strides in the technology and an increase in applications. The vast majority of these applications have to do with genomics and, now, proteomics. |
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09:35 |
DNA Array Diagnostics in the Clinic: A Critical Update
Bertrand Jordan, Marseille-Nice Genopole
Contrary to high expectations, DNA arrays penetrate only slowly into diagnostics. The reasons for this are diverse and have much to do with the difference in environment and objectives between the research and diagnostic laboratory. |
| 10:05 |
Coffee Break and Networking in Exhibition Hall |
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10:50 |
Array Comparative Genomic Hybridization (array-CGH) as Primary Tool in Diagnosing Constitutional Genetic Abnormalities
Karoly Szuhai, Group Leader, Leiden University Medical Center
This presentation illustrates the role of array-CGH both in diagnostic and research setting in constitutional genetic alterations. |
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11:20 |
Tiling Array Analysis of DNA Copy Number Variation
Herbert Auer, Director of the Functional Genomics Core, Institute for Research in Biomedicine
DNA copy number variations (CNVs) are the newly discovered contributors to genetic variation. Tiling array analysis of CNVs provides at least ten-fold higher resolution compared to other microarray platforms and can be applied to a broad range of organisms. |
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11:50 |
Functional Genomic Driving Individualized Medicine Towia Libermann, Assocate Professor of Medicine, Beth Israel Deaconess Medical Center
Functional genomics approaches are providing the basis for groundbreaking discoveries with bench-to-bedside clinical applications. Novel bioinformatics approaches for biomarker discovery and genomic and proteomic approaches in patients with cancer and other diseases will be presented. |
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12:20 |
Lunch & Poster Viewing |
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14:00 |
Analysis of Stage-Specific Non-Protein Coding RNAs in Prostate Carcinoma
Antje K. Kretzschmar, Group Leader, Fraunhofer Institute for Cell Therapy and Immunology |
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14:30 |
TF Chips to Monitor a Particular Level of Cellular Control
Véronique Mainfroid, R&D Team Leader, Eppendorf Array Technologies
Transcription factors (TF) are key cellular regulators, whose activation is closely associated to highly specific events. TF Chips are microarray-based assays developed to monitor the activation of these attractive biological markers. First applications are MAP kinase cascades and stem cell biology. |
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15:00 |
Coffee Break and Networking in Exhibition Hall |
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15:45 |
Small RNAs, Great Challenge – MicroRNAs on Microarrays
Stefan Wild, Senior Scientist, Miltenyi Biotech
MicroRNAs (miRNAs) are presumed to be key regulators of gene expression.1,2 , To investigate miRNA expression, a new microarray platform allowing selective detection of most known miRNAs (miRBase 10.0)4 and data showing remarkable consistency with cloned miRNA libraries will be presented. |
| 16:15 |
Automated Production of Functional Hepatitis C ProteinMicroarrays on 3D Substrates Using Inkjet
Dr Holger Schulze, University of Edinburgh
In this presentation we report on the production and reproducible nature of functional hepatitis C virus (HCV) antigen microarrays printed on 3D porous substrates with the Arrayjet Super Marathon.
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16:45 |
Microarrays from A to Z: Automated Microarray Production and Data Collection using Geniom® Technology
Peter Roberts, Manager, Febit Biomed
GENIOM’s microfluidic platform enables automated microarray production and processing. By reducing the amount of hands-on steps required by the user, the platform gives inexperienced microarray users access to cost-effective flexible arrays and data. |
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17:15 |
On-Chip Diagnostic Immunoassays of Panels of Bioselected Tumor Antigens: Binding to Serum Autoantibodies for the Early Detection of Cancer
Michael A. Tainsky, Karmanos Cancer Institute Wayne State University School of Medicine |
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17:45 |
Towards Deployable, Portable, Arrayed Biosensors
Dr Levi Gheber, Researcher, Ben-Gurion University
Portable biosensor arrays will revolutionize our lives, being deployed in large amounts in hard-to-reach locations, and reporting on multiple threats in real time. |
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18:15 |
Drinks Reception for sponsorship opportunities please contact paul.raggett@selctbiosciences.com |
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Day 2 - 8 May 2008 |
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08:00 |
Microarray Techonology
Chaired by Steven Bodovitz Principal BioPerspectives |
| 08:05 |
Microchip-based Sequencing through Styling the Inactiviation/Reactiviation of Arrayed Primers
Kai Li, Professor, University of Suzhou
This is a new microarray based sequencing method, highly applicable for the $1000 genome project. |
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08:35 |
Advances in Bioarray Production using Inkjet Technology
Iain McWilliam, Senior Scientist, Arrayjet
Inkjet microarrayers have come of age; once the reserve of specialist facilities they are now used globally in research labs and production centres for diverse microarray applications. An introduction to inkjet technology will be followed by examples of its use.
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09:05 |
Reverse Phase Protein Microarrays and Multiplexed Microspotimmunoassays:
Ulrike Korf, Doctor, Division of Molecular Genome Analysis |
| 09:35 |
Making it Small: Protein Microarrays - Applications and Future Challenges
Thomas Joos, Head of Biochemistry Department, University of Tübingen |
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10:05 |
Antibody-Based Microarrays: From Focussed Assays to Proteome-Scale Analysis
Christer Wingren, Associate Professor, Lund University |
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10:35 |
Coffee Break & Networking in Exhibition Hall |
| 11:25 |
Microarrays: Expanding applications and associated fabrication challenges.
Dr John Austin, CSO, Aushon Biosystems |
| 11:55 |
Kinetics of Multiplex Hybridization on Microarrays
Steve Blair, Associate Professor, University of Utah
Cross-hybridization and spot to spot cross talk are problems in the interpretation of microarry data, especially as the complexity of array-based assays grows.Multiplex reactions can be reasonably described using a three-component kinetic model, where cross-hybridization is explicitly accounted for, enabling new assay methodologies based upon real-time data acquisition. |
| 12:25 |
Lunch & Poster Viewing |
| 13:55 |
Tissue Microarrays and Image Analysis
Chaired by William Gallagher, Professor, University College Dublin, Ireland |
| 14:00 |
Tissue Microarrays In Translational Medicine
Stephen Hewitt, Clinical Investigator, National Cancer Institute
Tissue Microarrays are a multifaceted tool bridging basic science to patient care, through histopathology. They have become an essential tool of translating science to medicine. |
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14:30 |
Antibody-Based Proteomics for Biomarker Discovery
Fredrik Ponten, University of Uppsala
Antibody-based proteomics allows for mapping of protein expression patterns in a multitude of normal and cancer tissues. At present 3.000 new genes/proteins are beeing analyzed annually within the HPA project (www.proteinatlas.org). As part of this effort candidate markers with potential clinical relevance are being discovered and further evaluated in tissue microarrays containing large cohorts of defined tumors. |
| 15:00 |
Coffee Break & Networking in Exhibition Hall |
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15:30 |
Tissue Microarrays, Digital Slides and Biomarker Development: Case Studies in Breast Cancer and Toxicology
William Gallagher, Associate Professor, University College Dublin
Tissue microarrays and digital slides as translational research tools. Bridging from omic discovery to validation. Manual and automated image analysis and case studies in cancer and toxicology. |
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16:00 |
High Throughput Strategies for the Analysis of Tissue Microarrays
Donal O'Shea, CEO, SlidePath LImited
High throughput workflows are essential to the elimination of the current bottlenecks in the analysis for the analysis of tissue microarrays. Novel approaches for the analysis of TMAs will be
addressed, including high throughput manual scoring and the application of computer aided image analysis to automated scoring. |
| 16:30 |
Detailed and Multiplexed Qantification of Biomarker Expression in the Context of Relevant Morphological Units
Martin Baatz,Vice President Advance Technology, Definiens AG
The sample cases demonstrate that technology is available which is capable to automatically and systematically provide detailed,
multiplexed quantification of biomarkers in the context of precisely detected specific morphological structure.
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17:00 |
An optimized aCGH method for use with FFPE tissue samples.
Ernie Guzman, Scientist, Invitrogen
We describe a method to purify and label FFPE DNA for aCGH using Invitrogen's BioPrime Total Genomic Labeling System. The purification uses an FFPE specific protocol with the PureLink Genomic DNA Purification System coupled to a modified BioPrime Total Labeling kit. |
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17:30 |
Close of Conference
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