MCR-Chemistry Short Course
9-12 AM (3 hours)
1. Introduction Background
MCR definition, classifications, (dis)advantages.
2. General References
How to use the script, literature, sites.
3. IMCR (I)
Isocyanide reactivity, synthesis of isocyanides, stereospecificity of IMCRs, Passerini reaction and secondary transformations;
(Break 10:30 – 10:45 am)
4. IMCR(II)
Basic Ugi reactions; secondary transformations; UDC; isocyanoacetamide chemistry, library chemistry around Schoellkopfs isocyanide;
(Lunch 12:00 – 1:00 pm)
1:00 – 5:00 PM (4 hours)
5. IMCR (III)
Groebcke; one backbone - multiple accesses by IMCR; van Leusen IMCR; DMAD IMCR; other IMCRs; applications
(Break 3:00 – 3:30 pm)
6. Other MCRs
α-Aminoalkylations (Mannich, Betti, Petasis, Beller); Biginelli, Diels Alder; Hantzsch, Boennemann, reactions catalysed by metals;
7. Outlook
Emerging applications – the future of MCR chemistry; computational MCR; databases, webpages.
9. Q & A Session