ADME: Creating Optimised Drug Candidates from Active Molecules
Exploring Reciprocity: Dynamic Evaluation of ADME Properties
These pre-conference training courses are being held on the first day of the ADMET Europe conference. Talks will commence on the second day.
What will I gain by attending?
Part 1 (09:00-12:30)
ADME: Creating Optimised Drug Candidates from Active Molecules
• Appreciate the need for ADME studies from a historical R&D perspective
• Review current regulatory guidances
• Review ADME parameters and models (in vitro and in silico)
• Perceive the interdependence of ADME properties and chemical structure
• Construct ADME/DMPK benchmarks on the basis of preclinical and clinical plans
• Understand and appropriately choose in vitro/in silico models
• Ability to evaluate ADME data in diverging compound contexts
• Apply ADME tools to case studies (taken from discovery and early preclinical stages)
Part 2 (13:30-17:00)
Exploring Reciprocity: Dynamic Evaluation of ADME Properties
• Create ADME screening strategies for alternative optimisation goals
• Develop integrated sequences of in vitro screening and early in vivo PK
• Appreciate the need for continuous cross-disciplinary ADME application at all R&D stages
• Decide on outsourcing needs, strategies and interfaces
• Apply ADME tools to case studies (taken from discovery, preclinical and clinical stages)
• Discuss emerging strategies and regulatory trends
Who should attend?
These seminars are suited to academics interested in industrial applications of drug metabolism research, as well as industry professionals with little practical experience of ADME/DMPK concepts wishing to independently evaluate ADME data.
Part 1 is an introductory course particularly recommended to scientists and project managers with a background predominantly in chemistry, pharmacology or medicine.
Part 2 deals mainly with the dynamic application of ADME models/data in variable discovery settings and the most productive integration of ADME activities in the overall R&D process. It is of relevance to the participants of Part 1 as well as professionals with some experience of practical ADME data application in project management.
The courses require no previous knowledge of ADME concepts
- Medicinal Chemists
- Academics
- Programme and Project management
- Chemistry/Pharmacology scientists with R&D management responsibilities
- Clinicians and Clinical PK experts wishing to explore ADME connection to PK /DDI
Course topics
- Emergence of ADME as a co-decisive discipline in pharma R&D
- Absorption, Distribution, Metabolism and Elimination processes explained
- Interplay of physicochemical parameters and ADME properties
- Overview of in vitro ADME models (PAMPA, Caco-2, metabolic stability etc)
- Overview of early DDI prediction models (CYP inhibition/induction, transport)
- Design considerations for in vitro models (including reference to current guidance)
- Role of in vitro ADME data for (pre)clinical strategies and predictions - Use of in vitro ADME data in early PK evaluations
- Balanced optimisation vs. maximisation of isolated parameters
- Dynamic application of ADME space to variable project goals