Two Pre-Conference Short Courses:
(1) When The Path Matters More Than the Destination – Drug Metabolism Made Simple
9.00 - 12.30 , 19 Feb 2007 by Dr.Corinne Kay of Med-Simple (Biography)
What will I gain by attending?
- Learn the key elements of the human digestive system and their relevance to ADME
- Master the basic concepts of ADME and their impact on drug discovery.
- Understand how to diagnose ADME issues in a project
- Discover working solutions to ADME issues taken from marketed drugs and the literature
- Learn a method for productive reading of the literature
Who should attend?
The workshop is suited to people in academia that have an interest in current issues in the drug discovery process. It is particularly recommended to medicinal chemists who have recently joined the pharmaceutical industry and more experienced medicinal chemists who wish to pull together a range of notions they have picked up in the course of their projects.
The course requires no previous knowledge of the topic
- Medicinal Chemists
- Process Chemists
- Academics
Topics for the ADME course:
- Absorption, Distribution, Metabolism and Elimination
- CYP 450’s, and liver induction
- Phase 1 & 2, biliary excretion and enteropathic cycling
- Solubility, permeability and pgp
- Glomerular filtration
- Oral absorption and bioavailability
(2) hERG – The ‘Bête Noire’
14.00 - 17.30 , 19 Feb 2007 by Dr. Corinne Kay of Med-Simple (Biography)
What will I gain by attending?
- Gain insight on the hERG channel including structure and function
- Understand issues associated with long QT syndrome (LQTS) and torsade de pointes (TDP)
- Gain an overview of the hERG pharmacophore models and their limitations
- Become familiar with hERG assay methodologies and biological results interpretation
- Discover strategies for designing out hERG activity through a comprehensive literature survey
- Obtain an overview of attrition, reasons for project failure
- Learn a method for productive reading of the literature
Who should attend?
The workshop is particularly recommended to medicinal chemists who have recently joined the industry and wish to gain insight into this important area as well as to sharpen their literature reading skills. It is also suited to people in academia that have an interest in current issues in the drug discovery process. The course requires no previous knowledge of the topic
- Medicinal Chemists
- Process Chemists
- Academics
Topics for the hERG course: - The iKr Potassium Channel and associated long QT syndrome (LQTS) and torsade de pointes (TDP)
- ECG explained
- Biological assays
- Case studies including problem solving
- The role of DMPK
- Designing out hERG activity
- A comprehensive survey of the hERG literature
- Deviations from expected behavior
- FDA guidelines
Tutor Biography
Corinne Kay read Organic Chemistry at Lyon University, France (1984). She then joined Roche (1984-1990) as a medicinal chemist where she was involved in the Trocade as well as the Saquinavir projects. In addition, she had a key role in establishing a Solid Phase Peptide and Oligonucleotide synthesis facility in house. She then Joined Glaxo in 1990, where she has worked on a number of Protease and GPCR drug Discovery projects at various stages of lead discovery and lead optimisation. Corinne then obtained a GlaxoSmithKline sponsored PhD at the University of Cambridge (2000) having worked with Prof S V Ley, FRS on the discovery of novel solid phase amine linkers. She then joined Organon in 2001 where she became responsible for Medicinal Chemistry training of staff and more recently founded Med-Simple, a company specialising in applied Medicinal Chemistry training. She is the author of over 40 publications, book chapters and reviews in these areas. Her research interests include the design of chemical libraries, peptide synthesis, solid phase synthesis and ADME.