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Barcelona, Spain |
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Course Tutor :
John C. Owicki, Ph.D.
Previous Comments:
"Very good; I've learned so much and all the references are very useful"
Casper Berg (Danisco)
"Very informative. Depth of knowledge excellent"
Michael Martin-Short (Pfizer)
"Very good course especially for people working with enzyme assays"
Elizabeth Hamelink (Medivir)
"Content stimulated thinking"
Louise Young (SIDR)
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These courses are being held in conjunction with Screening Europe and MedChem Europe.
Register for either, or both, courses and you will automatically receive a full delegate pass to Screening Europe. This includes access to all sessions, the exhibition and refreshments during the event (regular price €785).
Fluorescence Assays in Drug Discovery
All day 19 February and morning of
20 February 2007
What will I gain by attending ?
- Master the basic concepts of fluorescence at the level required to understand fluorometric assays and instrumentation.
- Become familiar with the application of fluorometric assays to the major classes of pharmacological targets.
- Understand the basis and applications of advanced methods such as fluorescence imaging, fluorescence polarization, time-resolved energy transfer, and fluorescence-fluctuation spectroscopy.
- Learn the important types of interferences in fluorometric assays.
- Discover where to find more advanced information, using the extensive list of references provided.
Fluorescence course topics:
- Fluorescence fundamentals
- Labels and labeling chemistries
- Instrumentation
- Interferences and limitations
- Survey of principal fluorescence methods
- Biochemical and cellular applications
Enzyme & Binding Assays in Drug Discovery
Afternoon of 20 February and all day
21 February 2007
What will I gain by attending ?
- Master the basic concepts underlying enzyme and binding assays
- Learn how applications in drug discovery sometimes dictate assay optimization and interpretation which differ from textbook recommendations
- Learn how best to extract the information you need from your assays
Enzyme & Binding course topics:
- Enzyme kinetics
- Enzyme inhibition: Competitive, noncompetitive, uncompetitive, irreversible, and promiscuous
- Multiple-substrate enzymes
- Binding equilibria and kinetics
- Deviations from classical textbook behavior
- Optimizing enzyme and binding assays for primary vs. secondary screening
- Understanding mechanisms and extracting information from your data
- Discussion of commercial data-analysis and simulation software
- Case studies, including receptor binding, kinases, and proteases
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