These courses are being held in parallel with Screening Europe, MedChem Europe and ADMET Europe.
Register for either, or both, courses and you will receive a FULL DELEGATE PASS to the conferences FREE OF CHARGE. This includes access to all sessions, the exhibition and refreshments during the event.
Fluorescence Assays in Drug Discovery
All day 23 February and morning of
24 February 2009
Fluorescence Assays in Drug Discovery will commence at 8:30am for registration and coffee and will finish at 5:00pm on 23 February, recommencing on 24 February at 9:00am and finishing at 12:30pm.
What will I gain by attending?
- Master the basic concepts of fluorescence at the level required to understand fluorometric assays and instrumentation.
- Become familiar with the application of fluorometric assays to the major classes of pharmacological targets.
- Understand the basis and applications of advanced methods such as fluorescence imaging, fluorescence polarization, time-resolved energy transfer, and fluorescence-fluctuation spectroscopy.
- Learn the important types of interferences in fluorometric assays.
- Discover where to find more advanced information, using the extensive list of references provided.
Fluorescence course topics:
- Fluorescence fundamentals
- Labels and labelling chemistries
- Instrumentation
- Interferences and limitations
- Survey of principal fluorescence methods
- Biochemical and cellular applications
Enzyme & Binding Assays in Drug Discovery
Afternoon of 24 February and all day
25 February 2009
Enzyme & Binding Assays in Drug Discovery will commence at 1:00pm on 24 February for registration and coffee, and will finish at 5:00pm, recommencing on 25 February at 9:00am and finishing at 5:00pm.
What will I gain by attending?
- Master the basic concepts underlying enzyme and binding assays
- Learn how applications in drug discovery sometimes dictate assay optimization and interpretation which differ from textbook recommendations
- Learn how best to extract the information you need from your assays
Enzyme & Binding course topics:
- Enzyme kinetics
- Enzyme inhibition: Competitive, noncompetitive, uncompetitive, irreversible, and promiscuous
- Multiple-substrate enzymes
- Binding equilibria and kinetics
- Deviations from classical textbook behaviour
- Optimizing enzyme and binding assays for primary vs. secondary screening
- Understanding mechanisms and extracting information from your data
- Discussion of commercial data-analysis and simulation software
- Case studies, including receptor binding, kinases, and proteases