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Agenda
Day One - 16 October
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08:55 |
Welcome |
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Proteomics in Biomarker Discovery |
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09:00 |
High Performance Proteomics as a Tool in Biomarker Discovery
Helmut Meyer, Director, Medical Proteome Centre, Ruhr University Bochum
Working on biomarker discovery for liver cirrhosis the group could identify 3 biomarker candidates. Starting with microdissection, followed by 2D-DIGE, IHC and Western blotting they could identify and validate 3 proteins in patients’ sera which may be useful as biomarkers. |
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09:30 |
The Quest for Affective Disorder Biomarkers
Chris Turck, Head, Proteomics and Biomarkers, Max Planck Institute of Psychiatry
Proteomic technologies in combination with pathway analysis promise to be of great value in molecular medicine, particularly in the discovery and validation of disease markers. |
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10:00 |
Coffee Break and Networking in the Exhibition Hall |
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Proteomics Technology Development |
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10:45 |
Mass Spectrometry Detects Non-Covalent Binding of ATP to Growth Factors
Simone König, Docent for Biophysical Chemistry, Head of Proteomics Group, University of Münster
The interaction of growth factors with ATP is shown to be non-covalent. The stability of these complexes allows selective purification and mass spectrometric detection. |
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11:15 |
Target Molecule for the Antidiabetic Drug Discovery
Irine Sarvilina, Director, Novomedicina Medical Centre
The new target molecules for antidiabetic drugs. The proteomic technological platform for searching for the new molecules for drug discovery. Three-dimensional model of carboxypeptidase Z (isoform 1) and its active centre. Biological function of carboxypeptidase Z. |
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11:45 |
Quantitative Analysis of Single Amino Acid Changes using a 4000 QTRAP® System
Bruno Manadas, Postdoctoral Fellow, Centre for Neuroscience and Cell Biology
Use of mass spectrometry to quantify the mistranslation of CUG codon, due to the presence of ambiguous tRNA that can be charged with both leucine and serine, and its impact on the evolution of the Candida genus. |
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12:15 |
Lunch and Networking in the Exhibition Hall |
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13:15 |
Poster Viewing |
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14:00 |
Microscale Protein Fractionation to Enrich for Target Peanut Allergen Detection in Foodstuffs by nano-LC Q-TOF Tandem Mass Spectrometry
Hubert Chassaigne, Research Scientist, European Commission Joint Research Centre
The presentation given by Dr. Hubert Chassaigne reports on the progress of the research on food allergens and the development of confirmatory methods for the specific detection and identification of allergens in complex foodstuffs. |
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14:30 |
Quantitative Profiling of Breast Tumour Proteomes by Label-Free Multiple Reaction Monitoring Mass Spectrometry
Metodi Metodiev, Lecturer/Director of Proteomics Unit, University of Essex
The talk presents a novel approach to the analysis of protein biomarkers. It utilizes highly specific detection of diagnostic peptides by multi-stage mass spectrometry. The method is label-free alternative to conventional isotope-dilution methodology and can easily be translated to clinic. |
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15:00 |
Label Free Intrinsic Imaging and Proteomics
Judit Nagy, Proteomics Facility Director, Imperial College London
Proteomics needs more reliable and quantitative protein separation techniques. The group used Label Free Intrinsic Imaging for the separation of complex protein mixtures, quality checking their 2DE samples and validation of DIGE results. |
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15:30 |
Coffee Break and Networking in the Exhibition Hall |
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Arrays |
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16:15 |
Array-Based Oncoproteomics: Antibody Microarrays as a Tool for the Clinic
Carl Borrebaeck, Professor, Lund University
A high-performing, human antibody microarray technology platform, based on designed recombinant antibody fragments, will be presented. This platform has now been applied in more than ten different clinical studies particular for cancer diagnostics. These data will be discussed. |
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16:45 |
Presentation to be confirmed |
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17:15 |
Drinks Reception in the Exhibition Hall |
Day Two - 17 October
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Arrays (continued) |
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09:00 |
Presentation to be Announced |
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09:30 |
A Novel Approach to High Complexity Peptide Arrays
Volker Stadler, Group Leader, German Cancer Research Centre/PEPperPRINT
A new way to high complexity peptide arrays – combinatorial synthesis with amino acid toner particles, a laser printer, and microchips. |
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10:00 |
Coffee Break and Networking in the Exhibition Hall |
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10:45 |
Profiling the Antibody Repertoire in Disease
Dolores Cahill, Professor of Translational Science, Conway Institute, University College Dublin
Autoantibody Profiling as a Method of Biomarker Discovery in Autoimmune Diseases, Cancer and Diseases of Aging |
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11:15 |
Protein Microarrays as Tools for the Quantitative Analysis of Protein Networks
Ulrike Korf, Scientist, German Cancer Research Centre
Protein microarrays are a sensitive tool to yield quantitative data on changes of the phosphoproteome. Different approaches to monitor protein abundance and the turnover of protein phosphorylation in the microarray format will be presented. |
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11:45 |
Progression of Parkinson’s Disease - An Autoimmune Disease?
Helmut Meyer, Director, Medical Proteome Centre, Ruhr University Bochum
Progression of Parkinson's disease might be caused by autoimmune antibodies. Using protein biochips containing about 11.000 different human recombinant brain proteins, the group were able to identify specific autoantibodies which might be useful for early diagnosis or therapy control. |
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12:15 |
Lunch and Networking in the Exhibition Hall |
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13:15 |
Poster Viewing |
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Proteomics Applications and IP |
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14:00 |
Virus-Host Cell Interactions in a Vaccine Production Process: Proteomic Analysis of Influenza A Virus Infected Mammalian Cells by 2D-DIGE
Diana Vester, Research Assistant, Max Planck Institute for Dynamics of Complex Technical Systems
Here, the group present their efforts to use proteomic technology for optimization of a cell culture-based influenza vaccine production process. Therefore they compared changes in protein abundance that occur in typical vaccine production cell lines (MDCK, Vero) in response to human influenza A infection by 2D-DIGE. |
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14:30 |
Dynamic Activity of Lipid Droplet: Protein Phosphorylation and GTP-Mediated Protein Translocation
Pingsheng Liu, Professor, Institute of Biophysics, Chinese Academy of Sciences
Lipid droplets control the energy homeostasis that links to many human metabolic diseases. Using a comprehensive proteomic study, 125 proteins, 7 phosphorylated proteins including ADRP, Rabs, and ATGL, and recruitment of Arf1 and its coatomers to droplets were identified. |
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15:00 |
Poster Award |
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15:10 |
Coffee Break and Networking in the Exhibition Hall |
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15:50 |
Patent Protection in Proteomics
Clara Sattler de Sousa e Brito, Researcher, Max Planck Institute for IP / ISP, Yale Law School
The talk will present an overview of the range of Intellectual Property rights in the various areas in proteomics and will examine patentability and scope of protection of protein 3-dimensional structure related claims according to German, European and US law. |
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16:20 |
Presentation to be confirmed |
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16:50 |
Close of Conference | |