Lunchtime Workshop
1 May 2008
1:15 pm – 2:00 pm
David Dorris, PhD
Sr Director and General Manager, RNAi and Cell Biology
Applied Biosystems
Next Generation siRNA Technology for Improved Silencing Efficacy, Potency, and Specificity and Cleaner RNAi Results
Critical to siRNA experimental success is use of effective, potent, and specific siRNAs for silencing their respective targets. In the past year, we have embarked on a comprehensive program to improve siRNA performance using a combination of all new siRNA design parameters, updated bioinformatic filtering criteria, and novel chemical modifications. We will describe these efforts, as well as their impact on cell-based assay derived phenotypic data.