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SELECTBIO Conferences The Space Summit 2019

Joan Nichols's Biography

Joan Nichols, Professor, University of Texas Medical Branch at Galveston

Joan E. Nichols Ph.D. is currently a Professor of the both the Departments of Internal Medicine, Infectious Diseases and the Department of Microbiology & Immunology at University of Texas Medical Branch in Galveston (UTMB), Texas. Dr. Nichols has been involved in research projects examining alterations in immune response of the lung after exposure to pollutants and/or respiratory pathogens and has expertise in the areas of general immunology, inflammation, disease pathogenesis, stem cell characterization/differentiation, wound healing, transplantation immunology, lung defense and respiratory pathogens. Her research group has used adult and embryonic stem cells combined with tissue engineering techniques to produce human microphysiologic bioengineered human tissue models to study lung physiology and disease pathogenesis. Publication highlights include manuscripts demonstrating production of whole human acellular scaffolds, production of bioengineered pediatric lungs from adult lung cells and production and transplantation of bioengineered lung in a large animal, pig model.

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The Effect of Microgravity on Lung Stem Cell and Lung Physiologic Responses

Monday, 14 October 2019 at 15:30

Add to Calendar ▼2019-10-14 15:30:002019-10-14 16:30:00Europe/LondonThe Effect of Microgravity on Lung Stem Cell and Lung Physiologic ResponsesThe Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,

Human lung organoids were developed on site at Cape Canaveral Research Facilities.  Sets of 3D lung organoids +/- human macrophages were flown on the ISS from 8/13-8/22/2017.  Ground controls were shipped to Texas. Culture supernatant was isolated from ISS flown and ground controls every 5 days as were matched sets of organoids. Organoids were fixed and stored.  Analysis of samples has indicated that ISS flown samples showed differences in tissue formation, lung stem cell maturation, lung stem cell attachment to scaffold and surfactant production as well as dispersal compared to ground controls.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonThe Space Summit 2019The Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,