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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Asia 2022

Hardy TS Kagimoto's Biography

Hardy TS Kagimoto, Founder, Chairman and CEO, HEALIOS K.K.

Hardy TS Kagimoto, MD is founder, Chairman and CEO of HEALIOS K.K., a Tokyo-based, clinical-stage world leader in regenerative medicine and cell therapy.

After founding Healios in 2011, Dr. Kagimoto led the company’s listing on the Tokyo Stock Exchange in 2015. Healios leverages the favorable Japanese regulatory framework for regenerative medicine to efficiently deliver results for patients and its stakeholders. Healios is developing best-in-class, next generation pipeline assets in immuno-oncology, ophthalmology, and organ buds utilizing its innovative, proprietary universal donor iPS cell platform. In addition, it conducted two pivotal clinical trials for ischemic stroke and acute respiratory distress syndrome using bone marrow-derived allogeneic multipotent adult progenitor cells.

Dr. Kagimoto is a Kyushu University hospital trained medical doctor. Prior to founding Healios, he built and ran his first biotech company, Aqumen, and launched BBG250 which gained global de-facto-standard status as a surgical adjuvant in the ophthalmology community.

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Healios’ eNK Cells: Research, Development and Manufacturing of an Innovative Treatment for Solid Tumors

Thursday, 6 October 2022 at 16:30

Add to Calendar ▼2022-10-06 16:30:002022-10-06 17:30:00Europe/LondonHealios’ eNK Cells: Research, Development and Manufacturing of an Innovative Treatment for Solid TumorsLab-on-a-Chip and Microfluidics Asia 2022 in Tokyo, JapanTokyo,

HEALIOS K.K. (“Healios”) has developed engineered NK cells (“eNK” cells), a novel gene-edited NK cell therapy designed to possess excellent efficacy for solid tumors. Healios’ eNK cells are produced from a proprietary iPSC line, which has been genetically modified for enhanced anti-tumor activity. The eNK cell platform is uniquely differentiated from other approaches, having been engineered with five enhancements that are important for cancer killing activity. This comprehensive set of functional enhancements - and in particular unique migratory and immune cell recruitment features – position Healios’ eNK cells with the potential to penetrate solid tumors and, once there, initiate robust tumor killing activity. Preclinical studies have demonstrated superior antitumor activity of eNK cells in comparison to unmodified iPSC-derived and peripheral blood NK cells in vitro and in vivo. In addition, eNK cells have been generated in a high quality, clinical grade form and are currently manufactured in Healios’ in-house GMP facility at the Kobe Center for Medical Innovation utilizing a proprietary, automated, feeder-cell free 3D perfusion bioreactor system at an efficient scale of 100 billion cells per batch. Healios is continuing with its testing of eNK cells both in its laboratory facilities in Kobe as well as through joint research with several academic institutions. Healios has begun pre-clinical consultations with the PMDA and aims to begin clinical trials using eNK cells in 2024.

Add to Calendar ▼2022-10-06 00:00:002022-10-07 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Asia 2022Lab-on-a-Chip and Microfluidics Asia 2022 in Tokyo, JapanTokyo,