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SELECTBIO Conferences Innovations in Microfluidics & SCA 2022

John McGrath's Biography

John McGrath, Senior Scientist, Sphere Fluidics Ltd.

John McGrath, PhD is a Senior Scientist at Sphere Fluidics Ltd, UK. John’s work is focused on the industrialisation of picodroplet technology into commercial instruments. John was previously a Senior Researcher at the University of Glasgow (UK) where he developed acoustofluidic single-cell/ droplet manipulation systems. Prior to this, he held a postdoctoral position at the University of Virginia (USA), during which he designed, manufactured, and validated microfluidic impedance cytometry instruments for use in biomedical applications. John received a BSc (Hons) in Cell and Molecular Biology and a PhD in Biotechnology at Heriot-Watt University (UK), the latter of which was focused on developing microfluidic tools for sorting and/ or detecting waterborne pathogens. His research interests include high-throughput microfluidic single-cell screening and/ or sorting techniques, droplet microfluidics, acoustofluidics, microfluidic integration, and microfabrication.

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Development of a Novel Single Cell Encapsulation System

Monday, 21 March 2022 at 13:00

Add to Calendar ▼2022-03-21 13:00:002022-03-21 14:00:00Europe/LondonDevelopment of a Novel Single Cell Encapsulation SystemInnovations in Microfluidics and SCA 2022 in Boston, USABoston,

Sphere Fluidics has industrialized picodroplet (i.e. pL volume aqueous droplets in oil) technology to enable the screening of tens of millions of single cells and subsequently isolate rare or “high producer” cells. A new instrument is currently being developed at Sphere Fluidics, in partnership with Heriot-Watt University (UK), which enables the rapid and accurate encapsulation of cells in an emulsion of picodroplets of high monodispersity. The semi-automated system relies on closed-loop image-based feedback to enable the calculation of individual picodroplet volumes and subsequently regulate the input pressure of the fluid flow line(s) of the system to adjust and maintain droplet volume over long time periods. This reduces the potential effects of long-term drift in the fluid infusion system and bioassay results are improved due to the superior reproducibility of the cell encapsulation process. This modular system is designed with the objective to be integratable with Sphere Fluidics’ other patented technology to enable a range of novel microfluidic processes and analytics on single and pools of cells.

Add to Calendar ▼2022-03-21 00:00:002022-03-22 00:00:00Europe/LondonInnovations in Microfluidics and SCA 2022Innovations in Microfluidics and SCA 2022 in Boston, USABoston,