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SELECTBIO Conferences The Space Summit 2019

Elizabeth Blaber's Biography

Elizabeth Blaber, Assistant Professor, Rensselaer Polytechnic Institute (RPI); Research Scientist, USRA/NASA Ames Research Center

Elizabeth A. Blaber, Ph.D. is a Research Scientist and Principal Investigator with the Universities Space Research Association in Mountain View, CA, and in the Space Biosciences Division at NASA Ames Research Center. She earned her Bachelor of Medical Sciences (Honours) at the University of New South Wales, Sydney, Australia and her Ph.D. in Molecular Genetics and Biochemistry from the same University. Dr. Blaber has conducted research at NASA Ames Research Center for the last 8 years and throughout her career has aimed to further NASA’s human research and space biology programs by investigating the role of microgravity on stem cell growth and regenerative functions. Dr. Blaber has provided lead science support for over six spaceflight experiments, including several Space Shuttle missions (STS-131, STS-133 and STS-135), and two embryonic stem cell experiments (STL-1 and STL-2). In 2014, she was awarded a NASA Space Biology Spaceflight Grant as a Principal Investigator to investigate the role of the cell cycle in stem cell-based tissue regeneration during mechanical unloading in spaceflight. In 2016, Dr. Blaber was appointed as Project Manager of the GeneLab for High Schools Summer Training Program, a new Space Biology training initiative aimed at introducing high school students to space-based research and bioinformatics analysis. Dr. Blaber also serves as the Space Biosciences Task Lead for the NASA Academic Mission Services Contract, and is a member of the Governing Board for the American Society for Gravitational and Space Research. Dr. Blaber has been honored with several prestigious awards including the Thora W. Halstead Young Investigator Award and the NASA Early Career Public Achievement Medal.

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Stem Cell Regeneration in Space: Using Microgravity to Understand Earth-based Diseases

Monday, 14 October 2019 at 10:45

Add to Calendar ▼2019-10-14 10:45:002019-10-14 11:45:00Europe/LondonStem Cell Regeneration in Space: Using Microgravity to Understand Earth-based DiseasesThe Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,

During the last several decades of microgravity (mechanical unloading) research, significant progress has been made in the field of space biology that is shaping our understanding of how gravity regulates physiological processes. Exposure to microgravity during spaceflight results in tissue degeneration in multiple physiological systems including muscle atrophy, bone loss, immune deficiencies and cardiovascular impairment. Our ongoing studies with the mouse bone model have identified the failure of normal stem cell-based tissue regeneration, in addition to degeneration, as a significant concern for long-duration spaceflight, especially in the mesenchymal and hematopoietic tissue lineages. Our experimental work in microgravity flight experiments have aimed to investigate the molecular, cellular and tissue aspects of the hypothesis that gravity mechanical loading regulates tissue regenerative health and includes studies of mouse bone tissue regeneration on the US Space Shuttle/ISS and the Russian Biosatellite BionM1, newt tail regeneration on the Russian Satellite Foton M2 and M3 and mouse embryonic stem cells on the US Space Shuttle/ISS. Through the use of large-scale genomics data sets and computational analysis using cross-species comparisons, this work has identified a load-dependent molecular regulator that likely impairs tissue regenerative capabilities in unloaded environments. The results from this work hold the promise of greater scientific understanding of how to maintain and monitor health during future voyages of space exploration, and solidly establishes Earth’s gravity as a major shaper of human life through promoting tissue regenerative health. Additionally, as microgravity is thought to cause accelerated aging and onset of age-based disease phenotypes, including osteoarthritis, cardiovascular disease, and fibrotic liver disease, this research has broad applications to debilitating disease progression both in space and on Earth.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonThe Space Summit 2019The Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,