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SELECTBIO Conferences Flow Chemistry European Summit 2024

Noah Malmstadt's Biography

Noah Malmstadt, Professor, Mork Family Dept. of Chemical Engineering & Materials Science, University of Southern California

Noah Malmstadt is Professor at the University of Southern California. He received a BS in Chemical Engineering from Caltech and a PhD in Bioengineering from the University of Washington. Following postdoctoral work at UCLA, he joined the Mork Family Department of Chemical Engineering and Materials Science at USC in 2007. Malmstadt is the recipient of a 2012 Office of Naval Research Young Investigator award. His research focuses on microfluidic strategies to facilitate material fabrication and biophysical analysis. He has pioneered the integration of ionic liquids as solvents in droplet microreactors and the application of microfluidic systems to synthesizing biomimetic cell membranes. Microfluidic analytical techniques he has developed include methods for measuring the permeability of cell membranes to druglike molecules and techniques for measuring ionic currents through membrane proteins.

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ML-Assisted in situ monitoring of Flow Reactions for Sustainable Solvent Design

Tuesday, 26 March 2024 at 08:30

Add to Calendar ▼2024-03-26 08:30:002024-03-26 09:30:00Europe/LondonML-Assisted in situ monitoring of Flow Reactions for Sustainable Solvent DesignFlow Chemistry European Summit 2024 in Rotterdam, The NetherlandsRotterdam, The

The transition to a sustainable chemical manufacturing infrastructure requires a new approach to solvents: solvent waste must be recycled to reactor feed, closing the material cycle. Ionic liquid (IL) solvents represent a special class of low-volatility, generally safe solvents that are particularly easy to recycle. Recent work from our lab has demonstrated that automated millifluidic flow chemistry routes to IL recycling can reduce their total process cost to the point where they are competitive with traditional volatile organic solvents.

This talk discusses an exemplary application of IL solvents: the fabrication of colloidal catalyst nanoparticles (NPs). While the capacity to produce metallic NPs in ILs has been known for decades, we know little about the mechanism of these reactions and, in particular, how solvent choice can guide this mechanism. To discover the mechanism of Pt NP fabrication in ILs, we have constructed a flow reactor with in-line spectrophotometric monitoring of the products. To determine reaction component concentration from the complex spectral data, we have implemented a machine learning (ML) algorithm that can determine concentration. By measuring product concentration as a function of residence time, we are able to determine the IL solvent-dependent reaction kinetics.

Add to Calendar ▼2024-03-25 00:00:002024-03-26 00:00:00Europe/LondonFlow Chemistry European Summit 2024Flow Chemistry European Summit 2024 in Rotterdam, The NetherlandsRotterdam, The