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SELECTBIO Conferences 3D-Culture & Organoids 2019

Masatoshi Suzuki's Biography

Masatoshi Suzuki, Associate Professor, Department of Comparative Biosciences and Stem Cell & Regenerative Medicine Center, University of Wisconsin-Madison

Masatoshi Suzuki, D.V.M., Ph.D. is an associate professor in the Department of Comparative Biosciences and a faculty member of the Stem Cell & Regenerative Medicine Center at the University of Wisconsin-Madison. His current research is to apply stem cell technology to disease modeling and therapeutic applications for neuromuscular diseases. He has engaged in basic and translational studies using human neural progenitor cells, mesenchymal stem cells, and pluripotent stem cells to develop therapeutic strategies for amyotrophic lateral sclerosis (ALS), muscular dystrophy, and Pompe disease (glycogen storage disease type II).

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In Vitro Modeling of Neuromuscular Diseases Using Human Induced Pluripotent Stem Cells

Tuesday, 15 October 2019 at 11:00

Add to Calendar ▼2019-10-15 11:00:002019-10-15 12:00:00Europe/LondonIn Vitro Modeling of Neuromuscular Diseases Using Human Induced Pluripotent Stem Cells3D-Culture and Organoids 2019 in Coronado Island, CaliforniaCoronado Island,

Neuromuscular diseases are caused by functional defects of skeletal muscles directly via muscle pathology or indirectly via the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established in any major neuromuscular disease. Human induced pluripotent stem cells (iPSCs) have a great capacity to differentiate into skeletal muscle progenitor cells (or know as myogenic progenitors) and skeletal myocytes for use in treating and modeling neuromuscular diseases. Further, recent innovations in bioengineering provide multifactorial and multidimensional controlled platforms for biomedical research beyond the traditional culture systems. Specifically, patient-derived iPSCs can be applied to differentiate into mature skeletal myotubes using newly featured cell culture systems such as two-dimensional (2D) skeletal-muscle-on-a-chip and three-dimensional (3D) skeletal muscle organoids. These bioengineering approaches can more closely mimic the native cellular environment and pathology in culture. Skeletal myotubes derived from patient-specific iPSC lines are a valuable resource for studying neuromuscular disease mechanisms and testing potential drug therapies.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/London3D-Culture and Organoids 20193D-Culture and Organoids 2019 in Coronado Island, CaliforniaCoronado Island,