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SELECTBIO Conferences The Space Summit 2019

Xiaomeng Hu's Biography

Xiaomeng Hu, Scientist, University of California-San Francisco

Xiaomeng started to study biology in year 2007 and was focused during her undergraduate on microbiology and the microbiological environment. In her postgraduate years she developed her passion for biomedicine and investigated the immune response of solid organ transplantation in animal models. During the years as a PhD student and in her Postdoc years in the Transplant and Stem Cell Immunobiology Laboratory, she focused her research on stem cells and mechanisms to induce tolerance during allogeneic transplantations. Also the preventing and the treatment of heart vascular diseases as well as immuno-modulation were in her research focus.

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Immunological Senescence in Space Affects Stem Cell Behavior and Function

Monday, 14 October 2019 at 13:45

Add to Calendar ▼2019-10-14 13:45:002019-10-14 14:45:00Europe/LondonImmunological Senescence in Space Affects Stem Cell Behavior and FunctionThe Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,

Aging is associated with dysregulation of the immune response, which is also termed “immunosenescence.” Each part of the immune system is influenced to some extent by the aging process. However, adaptive immunity seems more extensively affected, and it is especially the T cells that are altered. In fact, the number and proportion of late-differentiated T cells (so called TEMRA cells), is higher in the elderly than in the young and their accumulation may contribute to the enhanced systemic pro-inflammatory milieu commonly seen in elderly individuals. We do not know exactly what causes these observed changes, but an understanding of the possible causes is now beginning to emerge. Spaceflight causes a suite of negative health effects that may be comparable to immunosenescence, which seems to be a key regulator of the regenerative capacity of tissue- and organ-specific stem cells. Specifically, studies examining the effects of bone healing (by mesenchymal stromal cells; MSCs) and vascular regeneration (by endothelial progenitor cells; EPCs) were performed using tissue mimics on chip to represent “semi-3D” architectures.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonThe Space Summit 2019The Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,