Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Circulating Biomarkers World Congress 2020

Antonio De Maio's Biography

Antonio De Maio, Professor, University of California-San Diego

The investigations conducted by my research team have been very innovative in many areas, particularly our pioneer work demonstrating the genetic contribution in the response to injury. We were among the first to use mouse genetic approaches to map modifier genes of the response to sepsis. Our subsequent studies have also shown the contribution of other factors, such as diet and sex, to the inflammatory response. Other studies from our group have shown the importance of lipid metabolism in the function of macrophages. Our interest in lipid metabolism has been extended to investigate how inhibition of the cholesterol biosynthetic pathway affects macrophage function and how the extracellular lipid environment modulates this cell polarization. More recently, we investigated how membrane phospholipids modulate the macrophage transcriptome. Other investigations by our research group focus on the pathophysiology of sepsis, in particular how metabolic pathways are altered during this condition. I also have extensive experience in glycobiology, including the characterization of cell surface glycoconjugates, modification of glycoproteins by inhibitors of the cholesterol biosynthetic pathways and analysis of O-GlcNAc modified ribosomal proteins.

I have made several important discoveries in the field of heat shock proteins, including the stabilization of translation by heat shock proteins. Moreover, I demonstrate that Hsp70, a cytosolic protein, was capable of getting inserted into lipid membranes and forming ion conductance pathways. These investigations have been followed for the characterization of the interaction of this protein with lipid membranes and their role in the extracellular environment as signaling molecules. I have also been investigating the potential therapeutic role of extracellular Hsp70 in the context of Alzheimer’s disease.

Antonio De Maio Image

Isolation of Human Urine Exosomes: Potential Markers For Disease Conditions

Tuesday, 18 February 2020 at 11:30

Add to Calendar ▼2020-02-18 11:30:002020-02-18 12:30:00Europe/LondonIsolation of Human Urine Exosomes: Potential Markers For Disease ConditionsCirculating Biomarkers World Congress 2020 in Coronado Island, CaliforniaCoronado Island,

The role of exosomes or extracellular vesicles as mediators of intercellular communication has gained a great deal of attention, particularly within pathological conditions. In addition, interest in them has emerged as potential biomarkers of pathological conditions. Exosomes have been detected in a variety of bodily fluids, such as blood, saliva, and urine. The study of exosomes in urine samples is ideal for the detection of disease markers because they can be easily obtained in abundant quantities in a non-invasive and painless fashion. We have systematically optimized the collection of human urine samples for the isolation of exosomes by differential centrifugation, including the time of collection, reproducibility, and conditions for storage. We have observed that glycoproteins within the membrane of exosomes provide a specific pattern in healthy individuals that opens the possibility that alteration in their presence may result in a disease signature. Based on this investigation, we are in conditions to evaluate the use of urine exosomes as markers for a variety of diseases.

Add to Calendar ▼2020-02-17 00:00:002020-02-18 00:00:00Europe/LondonCirculating Biomarkers World Congress 2020Circulating Biomarkers World Congress 2020 in Coronado Island, CaliforniaCoronado Island,