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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics World Congress 2018

Roger Kamm's Biography

Roger Kamm, Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, Massachusetts Institute of Technology (MIT)

Kamm is currently the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering at MIT, where he has served on the faculty since 1978. Kamm has long been instrumental in developing research activities at the interface of biology and mechanics, formerly in cell and molecular mechanics, and now in engineered living systems. Current interests are in developing models of healthy and diseased organ function using microfluidic technologies, with a focus on vascularization. Kamm has fostered biomechanics as Chair of the US National Committee on Biomechanics (2006-2009) and of the World Council on Biomechanics (2006-2010). Kamm currently directs the NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems. He is the 2010 recipient of the ASME Lissner Medal (American Society of Mechanical Engineering) and the 2015 recipient of the Huiskes Medal (European Society of Biomechanics), both for lifetime achievements, and is the inaugural recipient of the ASME Nerem Medal for mentoring and education. He was elected to the National Academy of Medicine in 2010. Kamm is co-founder of two companies, Cardiovascular Technologies and AIM Biotech, a manufacturer of microfluidic systems for 3D culture.

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Applications of On-Chip Models of Neurodegenerative Diseases

Tuesday, 2 October 2018 at 10:00

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With advances in iPS cell technology, microfluidics and organoid biology, we now have the capability to create models of single- or multi-organ function for studies of function in health and disease.  These models have numerous applications ranging from the fundamental study of multi-cellular interactions to screening for new agents to treat disease.  In this talk, the focus will be on models of the central or peripheral nervous system, and how these can be used to study neurodegenerative diseases.  Two models will be discussed.  In one, we use genetically modified neurons co-cultured with endothelial cells to examine bi-directional consequences of amyloid-beta on endothelial permeability and of compromised vascular permeability on neuron function.   A second example involves the development of a motor unit model and its application to ALS drug screening.

Add to Calendar ▼2018-10-01 00:00:002018-10-03 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics World Congress 2018Lab-on-a-Chip and Microfluidics World Congress 2018 in Coronado Island, CaliforniaCoronado Island,