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SELECTBIO Conferences The Space Summit 2019

Edward Kelly's Biography

Edward Kelly, Associate Professor, University of Washington

Dr. Kelly earned his PhD in Biochemistry from the University of Washington in the laboratory of Dr. Richard Palmiter, developing transgenic and knockout mouse models to study the function of the metal-binding protein metallothionein. Following a postdoctoral fellowship in molecular toxicology at the UW Department of Environmental Health with Dave Eaton, he ventured into Biotech, managing the Preclinical Bioanalytics group at Targeted Genetics Corporation, evaluating the safety and efficacy of gene therapies for diseases such as cystic fibrosis, rheumatoid arthritis and hemophilias.

Upon his return to academia, his research interests have stayed within the realm of preclinical biology. Active areas of research in the Kelly lab focus on ex vivo modeling of human organ physiology and toxicological responses to drug/xenobiotic challenge. These project makes use of “organs on chips” or microphysiological systems (MPS) populated with primary and stem-cell derived cell types to recapitulate two key ADME organs, the liver and kidney. Recent work is extending MPS technologies to model select human diseases as well as how organs respond to the extreme environment of microgravity on the International Space Station. Dr. Kelly holds the position of Associate Professor in the Department of Pharmaceutics, Adjunct Associate Professor in the Department of Environmental and Occupational Health Sciences and also serves as Co-Director of the Pharmaceutical Bioengineering Extension Program.

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Modeling Effects of Microgravity on Kidney Function with a Human “Kidney Chip”

Tuesday, 15 October 2019 at 13:00

Add to Calendar ▼2019-10-15 13:00:002019-10-15 14:00:00Europe/LondonModeling Effects of Microgravity on Kidney Function with a Human “Kidney Chip”The Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,

We have developed a 3D microphysiological system (MPS) model of the human kidney that recapitulates the functions of the proximal tubule as well as responses to toxic insults. To understand the effects of microgravity on kidney function, we sent our MPS to the ISS. Functional readouts included production of urinary biomarkers of acute kidney injury and metabolism of vitamin D after extended (>7 days) culture in microgravity.

Add to Calendar ▼2019-10-14 00:00:002019-10-15 00:00:00Europe/LondonThe Space Summit 2019The Space Summit 2019 in Coronado Island, CaliforniaCoronado Island,