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SELECTBIO Conferences Asia Diagnostics Summit 2018

John Brennan's Biography

John Brennan, Professor and Director, Biointerfaces Institute, McMaster University

Professor John Brennan holds the Canada Research Chair in Bioanalytical Chemistry and Biointerfaces (Tier 1) and is Director of the Biointerfaces Institute at McMaster and the Fraunhofer Project Center for Biomedical Engineering and Advanced Manufacturing at McMaster University. He is an expert in the development of biosensors and point-of-care diagnostics, with specific expertise in bioactive paper, high-throughput development of printable biomaterials, and development of solid-phase assays for diagnostics and small molecule screening. Dr. Brennan leads a research team of over 25 HQP and has published over 180 peer-reviewed papers, given over 120 invited presentations, and has been awarded several patents in the areas of POC diagnostics.

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Integrating Aptamer Technology with Paper-Based Point-of-Care Devices for Biomedical Monitoring

Monday, 5 November 2018 at 14:45

Add to Calendar ▼2018-11-05 14:45:002018-11-05 15:45:00Europe/LondonIntegrating Aptamer Technology with Paper-Based Point-of-Care Devices for Biomedical MonitoringAsia Diagnostics Summit 2018 in Taipei, TaiwanTaipei,

DNA aptamers and DNA enzymes (denoted as functional nucleic acids or FNA) are an emerging platform for development of point-of-care (POC) diagnostic devices.  In this presentation, I will first focus on the development of new aptamers and DNA enzymes for a range of key biomarkers and their integration into colorimetric and fluorimetric assays for a variety of targets, mainly in the area of infectious disease.  Methods to couple target binding to FNAs to produce a DNA strand as an output, and to then use the output DNA to initiate isothermal amplification (ITA), will then be described.  Finally, the printing of specific “modules” for recognition (FNA), amplification (via ITA) and detection onto paper devices will be described as a way to generate a range of new POC devices that allow facile detection of a range of clinical analytes.  Examples will be provided to demonstrate multi-step reactions on paper for ultra-sensitive detection of E. coli, C. difficile, MRSA and H. pylori.

Add to Calendar ▼2018-11-05 00:00:002018-11-06 00:00:00Europe/LondonAsia Diagnostics Summit 2018Asia Diagnostics Summit 2018 in Taipei, TaiwanTaipei,